Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays

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Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays.

In this study, Caco-2 permeability results from different laboratories were compared. Six different sets of apparent permeability coefficient (Papp) values reported in the literature were compared to experimental Papp obtained in our laboratory. The differences were assessed by determining the root mean square error (RMSE) values between the datasets, which reached levels as high as 0.581 for t...

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ژورنال

عنوان ژورنال: European Journal of Pharmaceutics and Biopharmaceutics

سال: 2017

ISSN: 0939-6411

DOI: 10.1016/j.ejpb.2016.12.027